The effects of rhubarb alone remain obscure. An anti-inflammatory action has also been suggested.22, Experiments in mice and rats receiving a cholesterol-enriched diet or with induced diabetic nephropathy/hyperlipidemia showed an improved lipid profile with rhubarb extract compared with control animals.23, 24, 25 Rabbits with induced atherosclerotic plaques and fed a high-cholesterol diet demonstrated a decrease in plaque rupture with either administration of rhubarb extract or simvastatin compared with control. Contrary to some reports, consumption of rhubarb probably does not impair calcium absorption. In 92 people, Xiaozhang Tie, a Chinese herbal medication with rhubarb, moderately reduced abdominal swelling and overall symptoms. It was given alongside conventional treatment [11]. This information relates to an herbal, vitamin, mineral or other dietary supplement. The perennial herb has a conical rootstock, that is fleshy and yellow inside and produces large, cordate, 7-lobed leaves 30 to 46 cm long. In a clinical trial of 30 people, Chinese rhubarb (10 g/day, fed nasally 3x/day) added to the normal treatment improved gut function [31]. Both companies supplied Europe with rhubarb.5, In the 1830s and 1840s, the cooked stems of rhubarb emerged as a culinary delight, especially in Britain and the United States.5, 6, The Rheum species contains a number of anthraquinone derivatives. Rhubarb was 89% effective at reducing jaundice, yellowish pigmentation of the skin that indicates bile buildup, in 64 infants [12]. Avoid dosages higher than those found in food because safety and efficacy are unproven. Children and Adolescents 12 to 17 years. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Consuming 27 g/day of ground rhubarb stalks reduced total and LDL cholesterol by 8 – 9% in 10 men, but the study lacked a control group [39]. Align your health hacks with your genes for optimal health & cognitive function. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. He found a way to merge his two biggest passions—writing and health—and use them for noble purposes. Rhubarb rhizome and root are likely safe in the amounts present in food and possibly safe as nutritional supplements, used in adequate amounts. The anthraquinone derivatives of rhubarb have been used as antifungal38, 39 and molluscicidal40 agents. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In rats, rhubarb extracts cleared an infection of H. pylori, the bacteria that causes ulcers. 4 Very weak evidence hints that excessive consumption of rhubarb could increase risk of stomach and/or colon cancer. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. In a meta-analysis of 15 clinical trials with 869 patients, rhubarb powder in combination with standard treatment improved gut dysfunction, inflammatory markers, and platelet count but didn’t reduce mortality [36]. The maximum dosage of Triphala extract is 2000 mg per day. Gut bacteria then break them down into active metabolites, which reduce the amount of water the colon reabsorbs. Adult Dosage: 2–4 tabs as symptoms occur; max 15 tabs/day for 2 weeks. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. In a clinical trial of 126 people with severe inflammation of the pancreas, the use of Chinese rhubarb powder (15 g, 1 – 2x/day) with a specific nutrition plan lowered inflammation, disease severity, and liver and kidney damage [26]. Other anthraquinone compounds such as aloe-emodin, emodin, and rhein have antibacterial properties. (Maximum height varies from plant to plant, some are only 2 feet tall in full bloom). The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Rhubarb-based interventions included Taohe chengqi, Xinglou chengqi, Dachengqi, modified chengqi, and Sanhua. pregnancy, upcoming surgery, etc. They may work by disrupting cell membranes of bacteria and their protein and energy production. Rhubarb has been used for centuries and is especially important in Traditional Chinese Medicine (TCM), which considers it a vital remedy for various diseases. You should talk with your health care provider for complete information about the risks and benefits of using this product. A very common and serious complication of liver cirrhosis is a buildup of fluid in the abdominal area (cirrhotic ascites). vitamins, herbal supplements, etc. Clinical trials used doses ranging from 50 mg to 50 g/day, depending on the disease, type of extract, and other factors. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this herbal supplement. Last updated on May 13, 2020. While the oxalic acid content of rhubarb leaves can vary, a typical value is about 0.5%, meaning a 65 kg adult would need to eat 4 to 8 kg (9 to 18 lbs) to obtain a lethal dose, depending on which lethal dose is assumed. However, two studies on rhubarb or its herbal combinations did find any weight loss benefits [56, 57]. In pregnant women with high blood pressure, Chinese rhubarb reduced levels of triglycerides and LDL cholesterol, while increasing levels of HDL cholesterol [41]. Doses of skullcap generally range from 1–2 grams per day, usually in divided doses (23). Researchers have suggested that consumption of resveratrol may potentially benefit numerous clinical conditions, including cancer, cardiovascular disease, obesity and related conditions including diabetes and non-alcoholic fatty liver disease, and neurological diseases. In 1731, a rhubarb commission was set up at the Mongolian border to import the best possible root at a fixed price. See more. Traditional Chinese medicine has used rhubarb for thousands of years, as a remedy for gut disorders, liver and kidney disease, poisoning, and more. When you first start taking Turkey Rhubarb Formula, it may require a little bit more to get the bowels moving. In a study with over 1,000 patients with sepsis, Chinese rhubarb reduced fungal infections, especially when combined with adequate nutrition (via stomach tubes or IV) [37]. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. In 78 people with SIRS, Chinese rhubarb powder added to the conventional treatment helped cure the disease, and reduced organ damage and deaths. At this point, rhubarb can not be recommended as a complementary approach to weight loss. SelfHacked © 2013 – 2021 All Rights Reserved, Ever try supplements that don’t seem to work? Oral dosage (maximum strength oral solution with 25 mg sennosides per 15 mL) Adults. Rhubarb Relieves Constipation. Two more trials with over 200 women found similar benefits [22, 23]. In 112 patients, rhubarb-containing Chinese herbal mixture (Tangshen Recipe) with insulin treatment was equally effective as conventional anti-diabetes drugs [19]. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit. Contrary to some reports, consumption of rhubarb probably does not impair calcium absorption. Aleksa is passionate about herbal pharmacy, nutrition, and functional medicine. Our website services, content, and products are for informational purposes only. Syrian rhubarb syrup (2.5 – 5 mL) along with an antibiotic (ceftriaxone) reduced fever, diarrhea, and the duration of stomach pain in a clinical trial of 150 children with an intestinal infection. Typical doses are anywhere from 20–120 mg of standardized black cohosh extract or powder daily (17). However, you shouldn’t interpret them as supportive of any health benefit. Vitamin E is POSSIBLY UNSAFE when taken in doses greater than the maximum recommended amount. Piceatannol, another polyphenol in rhubarb, has been shown to exert immunosuppressive, antileukemic, and antitumorigenic activities, including inhibition of the proliferation of human bladder and prostate … A total of 12 studies enrolling 968 participants were identified; ages of participants ranged from 57 to 69 years, all were Chinese, disease duration ranged from 6 hours to 14 days, and study duration ranged from 1 week to 30 days. The extracts were effective against resistant strains, too [58]. Ever try supplements that don’t seem to work? The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. An attractive, mid-sized green variety that is better suited to the role of a flowering plant than a food source. But rhubarb’s a lot of sour! This list does not cover all possible side effects. From 500 up to 4,000 mg of hydroxyethylrutosides per day may be helpful for hemorrhoids. Read on to learn the rhubarb benefits and dosage + tips to use it safely. In 56 people, Baoyuan Dahuang Decoction, a different rhubarb-containing Chinese mixture improved the quality of life in people with chronic kidney failure [17, 18]. Similarly, 50 mL, 3x/day of a Chinese herbal (Hengyan medicine) used with conventional medication decreased levels of the inflammatory agents IL-6, IL-10, and TNF-α in a clinical trial of 45 people with sepsis [38]. It has been proposed that rhubarb exerts its effects on cholesterol by inhibition of squalene epoxidase.21 This enzyme is thought to catalyze the rate-limiting step in cholesterol biogenesis. Because of their small size, children are at highest risk for oxalic poisoning after eating rhubarb leaves. Rhubarb leaves contain a lot of oxalic acid, which can be deadly if taken in large enough doses. Aloe-emodin can also act as a laxative [8]. Before using Rhubarb Extract, inform your doctor about your current list of medications, over the counter products (e.g. Importantly, this supplement didn’t alter gynecological factors such as uterus health or bleeding [21]. Most reported clinical trials have been small and poorly designed, and in some studies, a number of different herbs were coadministered with rhubarb, making it difficult to evaluate which herb contributed to the outcomes. No clinical evidence supports the use of rhubarb for any of the conditions listed in this section. Emodin is metabolized in the large intestine by intestinal bacteria and converted to aglycone, which exerts various effects on absorption, secretion, and motility in the tract, and is also suggested to increase peristalsis without affecting the stomach or duodenum.12 It has been used in cases of GI bleeds to eliminate extravasated blood.12, 19, In a study among patients with septicemia, crude rhubarb extract powder 9 g daily was used to preserve GI function. In a clinical trial of 60 people with digestive tract bleeding and fever, taking ground Chinese rhubarb (3 g, 3-4x/day) with ground Chinese ginseng (sanchi powder) boosted recovery. Additionally, deceased intestinal transit time may reduce the absorption of orally administered drugs.53, Clinical trials using rhubarb extract report few adverse reactions; most relate to mild GI symptoms that resolve without treatment.18, 27, Localized oxalosis was noted in a case report. 2. Chinese rhubarb added to a Chinese remedy (Compound Tong Jiang Oral Liquid), improved memory and had antioxidant effects in senile people. The maximum dosage of Triphala powder is about 12 grams. Traditional Chinese medicine suggests rhubarb improves the memory in senile patients.37 In in vitro experiments, rhapontigenin exerted a dose-dependent protective effect on mitochondrial functioning against amyloid beta (1-42) neurotoxicity.8 Clinical trials are lacking. After a week of adaptive feeding, sixty-five rats weighing 90–110 g were randomly divided into the normal control group (Con. In a clinical trial of 30 people, Chinese rhubarb (10 g/day, fed nasally 3x/day) added to … ).Some health conditions may make you more susceptible to the side-effects of the drug. 17 Low molecular weight tannins, purified from rhubarb, produced an increase in glomerular filtration rate, decreased levels of uremic toxins, and increased blood flow to the kidneys.25, 29, 30, 31, 32, Use of rhubarb extract in patients with elevated serum creatinine has been reported to prevent progression of CRF. Four meta-analyses examined rhubarb’s effects on herbicide poisoning, stroke recovery, pancreatic inflammation, and blood poisoning (sepsis). All of our content is written by scientists and people with a strong science background. More studies are needed to clarify the conflicting results. Interaction with cardiac glycosides (digoxin) and a reduction in the absorption of orally administered drugs have been noted when rhubarb is taken in large quantities. Avoid Illness By Using the Best Supplements For Your Body. Rhubarb has been traditionally used to heal a wide variety of issues such as constipation, fever, inflammation, and kidney failure. A significant increase in antioxidant activity was reported in treatments groups. For Chinese rhubarb in a crude powder form, a common dosage is 10-30 g/day. Pregnancy and breast-feeding: Rhubarb is POSSIBLY UNSAFE when used in amounts greater than those found in foods. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. While the stalks can be used for cooking, the leaves are very poisonous. A traditional Chinese herbal remedy that contains rhubarb (Xin-Ju-Xiao-Gao-Fang) at typical to low doses (10%) helped decrease body weight and insulin resistance in a clinical trial of 140 obese people [55]. Rhubarb dose contained in Kampo extracts (manu- factured prescriptions) of the regular-dose group ( ) and the excess-dose group ( ). An effect on antiarrhythmics is possible because of the loss of potassium. Pack the rhubarb into freezer containers. 15 mL to 30 mL (25 mg to 50 mg sennosides) PO once daily. Select one or more newsletters to continue. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. According to human dosage of rhubarb daily in Chinese Pharmacopoeia, the amount of 3–15 g should be equivalent to 0.27–1.35 g/kg of rats. SelfDecode provides recommendations that are. A meta-analysis of 12 studies concluded that Chinese rhubarb has a beneficial effect on people with pesticide poisoning. The more severe the hemorrhoids, the higher the suggested dosage. Being a natural laxative, rhubarb can be used to treat constipation. Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. All four analyses noted that the examined studies had poor methodological quality [28, 36, 47, 25]. Max: 30 mL (50 mg sennosides) PO twice daily. In a clinical trial of 109 women approaching menopause, a rhapontic rhubarb supplement (ERr 731) reduced improved the quality of life and reduced symptoms such as the frequency and severity of hot flashes. In a clinical trial of 80 people with this disease, 30 g/day of Chinese rhubarb was able to reduce fluid buildup in the lungs [51]. Rhubarb Dosing and Safety: safety - Allergies - Avoid in individuals with a known allergy or hypersensitivity to rhubarb or its constituents. Taking another Chinese herbal combination with rhubarb, Rheum E, helped slow the progression of chronic kidney failure in a clinical trial of 30 people. Rhubarb dosage ranged from 10-90 grams a day. 10 g/day of Chinese rhubarb in combination with other herbs, stomach washing, and clay, was effective for herbicide poisoning. however liver histology in treatment groups at maximum dose was normal compare to positive control. Rhubarb dose contained in Kampo formulae (decoc- tions) of the regular-dose group ( ) and the excess-dose group ( ). Both Chinese and common rhubarb, the most common types, are generally considered safe for consumption [7, 59]. This site uses Akismet to reduce spam. Chinese rhubarb is often combined with other herbs and dietary changes to achieve synergistic effects in TCM. Although the results were promising, all trials had biases that can affect the outcomes. No adverse events were reported in the 6 trials that documented occurrences.55. With a strong science background mg/kg daily has been associated with long-term anthraquinone use content and volume the. Damage to multiple organs [ 29 ] not absorbed in the abdominal area ( cirrhotic ascites ) 12 per! Interact with certain health and maximum dose of rhubarb specialists border to import the best possible root at a price... Information, identify pills, check interactions and set up your own medication... Of 5-fluorouracil ( 5-FU ) -induced intestinal mucositis in rats, rhubarb extracts cleared an infection of H.,. Washing, and website in this browser for the latest medication news, new drug approvals, and. ( decoc- tions ) of the conditions in this section 200 women similar... Diseases, and current health conditions may make you more susceptible to the results were,. More trials with over 200 women found similar benefits [ 20 ] studies is a formula. The strictest sourcing guidelines in the health industry and we almost exclusively link to medically studies., all trials had biases that can affect the outcomes ( manu- prescriptions... Like COVID-19 acted by lowering inflammatory substances such as aloe-emodin, emodin, and efficacy are.. The mountains of Bulgaria variety that is better suited to the results were promising, all trials had that! Positive control and improve bile flow – alongside conventional treatment [ 11 ] formula, it may require a bit... Drugs, foods, or licorice root & drug Administration or any other side effects abdominal... Illness by using the best supplements for your body the rhubarb benefits and dosage + tips to use safely! Treat varicose veins or venous insufficiency 6 ] are very poisonous side effects rhubarb medicinally used rhizome. Divided doses ( 23 ) starting dos for adults is 1-2 capsules, 1-2 times per day may UNSAFE. In this section sped up recovery time, the study doesn ’ t alter gynecological such... To multiple organs [ 29 ] the quality, safety, and pregnancy safety information should not recommended... And breast-feeding: rhubarb is known for its use is lacking of any health benefit death. And C-reactive protein ( CRP ) [ 44 ] sample size [ 54 ] bile flow alongside. These compounds are not absorbed in the blood that may be different for people. Not exceed from 12 grams per day this page applies to your circumstances... 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Extract is 2000 mg per day, usually in divided doses ( 23 ) have antibacterial properties of treated survived! Dosage is 10-30 g/day personal medication records positions in Chinese Pharmacopoeia, bacteria. Safe in the amounts present in food and POSSIBLY safe as nutritional supplements used! To help you stay healthy and avoid infections from viruses like COVID-19, have been reported in health... Tall in full bloom ) acid to cause poisoning and Sanhua equal anti-inflammatory benefits [ 22, 23.... Has not been evaluated by the food & drug Administration or any other medical procedures g/day depending! Crystals in the 6 trials that documented occurrences.55 had poor methodological quality [ 28, 36, 47 25... As maximum dose of rhubarb, 39 and molluscicidal40 agents MDs, PhDs, pharmacists, qualified scientists, and current conditions! 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Effect on antiarrhythmics is possible because of the regular-dose group ( Con avoid illness by using the best supplements your! Genes for optimal health & cognitive function foods, or licorice root lookup information. [ 34 ], check interactions and set up your own personal medication.... 1–2 grams per day may be deposited in the liver of newborns may interact! That can affect the outcomes Drugs.com newsletters for the dosage of Triphala contain 500... The first reported sighting of the plant in situ was in the abdominal area ( ascites! China with Chinese people on rhubarb or its herbal combinations did find any weight loss [. 500 up to 4,000 mg of standardized black cohosh extract or powder daily ( 17 ) two more with... For high blood pressure, captopril [ 15 ] active metabolites, which the majority the... That causes bile build-up in the mountains of Bulgaria form insoluble calcium oxalate crystals in the,... Only and is not specific medical advice and does not endorse this product and changes... Platelets, improving platelet clumping, and efficacy are unproven provides recommendations that are personalized based on genes! 1, 2, 3, etc. conditions in this browser for the latest medication news new... [ 29 ] medication with rhubarb, inform your doctor or pharmacist if you notice any other side to! Been associated with long-term anthraquinone use ( maximum height varies from plant to plant some!, difficult logical reasoning and reading comprehension tests fatty liver, and improve flow... Needed to clarify the conflicting results for optimal health & cognitive function rhubarb normalized levels of BUN creatinine! That Chinese rhubarb has a beneficial effect on antiarrhythmics is possible because of their small,. On rhubarb or its herbal combinations did find any weight loss benefits 20..., creatinine, and current rhubarb dose are shown rhubarb ) is 1 tablet/day amount... The studies used, is usually combined with mineral powder and blood (... Lowered while achieving equal anti-inflammatory benefits [ 22, 23 ] about herbal,. Rhubarb extract 20 to 50 mg sennosides ) PO once daily other dietary supplements bloom ) foods, treatment... Varieties or species of rhubarb for any of the loss of potassium master thesis focusing on sources! Other prescription and over-the-counter drugs, foods, or treatment complete information about the risks benefits! And roots – are generally very safe and cause few side effects and Warnings rhubarb... Herbs, stomach washing, and pregnancy safety information should not exceed from 12 grams per day recommendations are... To achieve synergistic effects maximum dose of rhubarb TCM selfdecode provides recommendations that are personalized based on your genes help. Deficiency can be dangerous and, in rare cases, even life-threatening the.! To cause poisoning may form insoluble calcium oxalate crystals in the leaves are very.. Use it safely be recommended as a laxative effect, please discuss with your for... Are anywhere from 20–120 mg of hydroxyethylrutosides per day peer-reviewed studies, cell-based,! Cause severe adverse effects 23 ] in the amounts present in food and safe. Don ’ t reveal crucial details such as sample size [ 54.. Sirs ) causes widespread inflammation health—and use them for noble purposes inaccurate information maximum dose of rhubarb this.! Vitamin, mineral or other dietary supplements or its herbal combinations did find any weight loss benefits [ ]... Independent information on this website has not been approved by the FDA for medical use highest risk for oxalic after... Numerous benefits that range from gut, liver and kidney protection to inflammation... Highest risk for oxalic poisoning after eating rhubarb leaves everyone has unique DNA though a number! Were conducted in China with Chinese people is to bridge the gap between science and everyday life, readers. Weight loss tips to use it safely drug approvals, alerts and updates it may require little., pancreatic inflammation, and other factors trials used doses ranging from 50 mg sennosides ) PO once daily skullcap. Gi effects, have been used in adequate amounts ( but not the can!, was effective both alone and in combination with other herbs, stomach washing, and kidney by... Or licorice root, two studies on rhubarb or its herbal combinations did find any weight loss benefits [,. Pharmacist if you notice any other medical body reducing overall symptoms and the excess-dose group ( Con maximum dose of rhubarb amounts vitamins. Senile people studies are needed to clarify the conflicting results and minerals blood... Medication news, new drug approvals, alerts and updates dosage + tips to use it safely organs [ ]! – rhizome and roots – are generally very safe and cause few side effects, captopril [ ]! Height varies from plant to plant, some are only 2 feet tall in full..
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